Nano-CRISPR支架（Nano-CD）
| 【Numbering】BKMC128004 | 【CAS】CAS | ||
| 【Item No.】BKMC128004-2 | 【specification】 | ||
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名稱：Nano-CRISPR支架（Nano-CD）
組成：氨基酸修飾的PEI + CRISPR/dCas9質粒+ 順鉑+ TAT+ 聚乙二醇化聚丙烯酸(PAA)骨架
粒徑：100-200nm
應用：離子視覺傳感
儲存條件：-4℃
其他說明：密封狀態下保質期半年【主要優勢】Nano-CD利用從功能篩選中選擇的特定sgRNA觸發內源性GDSME表達，同時釋放順鉑啟動免疫細胞死亡。此外其可以聯合檢查點阻斷可產生持久的免疫記憶和強大的全身抗腫瘤免疫反應，從而預防疾病復發，抑制肺轉移，提高小鼠黑色素瘤的生存率。
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組成：氨基酸修飾的PEI + CRISPR/dCas9質粒+ 順鉑+ TAT+ 聚乙二醇化聚丙烯酸(PAA)骨架
粒徑：100-200nm
應用：離子視覺傳感
儲存條件：-4℃
其他說明：密封狀態下保質期半年【主要優勢】Nano-CD利用從功能篩選中選擇的特定sgRNA觸發內源性GDSME表達，同時釋放順鉑啟動免疫細胞死亡。此外其可以聯合檢查點阻斷可產生持久的免疫記憶和強大的全身抗腫瘤免疫反應，從而預防疾病復發，抑制肺轉移，提高小鼠黑色素瘤的生存率。
Title:A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
Article link:https://www.163.com/dy/article/HTFL7SKO0534TMVS.html
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