自組裝結構Mito-PISA
| 【Numbering】BKMC102002 | 【CAS】CAS | ||
| 【Item No.】BKMC102002-2 | 【specification】 | ||
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Name: Self-assembled structure Mito-PISA
Composition: aromatic molecule monomer, TPP
Particle size: network shape, diameter of 50-100nm
Application: Regulation of cancer cells
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [main advantages]
1, high reactive oxygen species (ROS) concentrations in tumor mitochondria can lead to the formation of polymeric disulfide bonds. Because of the reducing environment, this polymerization hardly takes place elsewhere in the cell. It was shown that polymerization of thiol-containing monomers would further increase ROS levels within the mitochondria, which automatically catalyzes the polymerization process and generating fibrous-like polymerization structures.
(2) Experimental results show that this process will induce mitochondrial dysfunction, and then activate cell necrosis. In conclusion, this in situ polymerization system has broad potential for cancer treatment and against drug-resistant cancers.
Title:Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate
Article link:https://www.sogou.com/link?url=DSOYnZeCC_qqiTNYDsEp-hN55sPA_JdbNUqAS-fQLJrr3xX9ZTojqbbAp6VRqT6Q
Message
Composition: aromatic molecule monomer, TPP
Particle size: network shape, diameter of 50-100nm
Application: Regulation of cancer cells
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [main advantages]
1, high reactive oxygen species (ROS) concentrations in tumor mitochondria can lead to the formation of polymeric disulfide bonds. Because of the reducing environment, this polymerization hardly takes place elsewhere in the cell. It was shown that polymerization of thiol-containing monomers would further increase ROS levels within the mitochondria, which automatically catalyzes the polymerization process and generating fibrous-like polymerization structures.
(2) Experimental results show that this process will induce mitochondrial dysfunction, and then activate cell necrosis. In conclusion, this in situ polymerization system has broad potential for cancer treatment and against drug-resistant cancers.
Title:Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate
Article link:https://www.sogou.com/link?url=DSOYnZeCC_qqiTNYDsEp-hN55sPA_JdbNUqAS-fQLJrr3xX9ZTojqbbAp6VRqT6Q
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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