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HT-LT NPs

HT-LT NPs

【Numbering】BKME110004 【CAS】CAS
【Item No.】BKME110004-2 【specification】
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Name: HT-LT NPs
Composition: Hyaluronic acid-d- α -tocopherol succinate + heparin-TOS + doxorubicin (DOX)
Grain size: 80-200nm
Application: anti-tumor and tumor metastasis
Storage conditions: -4℃

Other instructions: shelf life of half a year under sealed state [Main advantages] HT-LT NPs diameter is about 125 nm, with high encapsulation rate and continuous drug release behavior. The 4T1 model demonstrated by HA binding to the CD44 receptor confirmed that HT-LT NPs exhibited efficient targeting capabilities both in vitro and in vivo. Moreover, HT-LT NPs acts at different stages of the invasion-metastasis cascade to inhibit the migration and invasion of tumor cells, thereby inhibiting tumor metastasis.

Title:Enhanced anti-tumor and anti-metastasis therapy for triple negative breast cancer by CD44 receptor-targeted hybrid self-delivery micelles
Article link:https://doi.org/10.1016/j.ijpharm.2020.119085


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