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T-DLHN

T-DLHN

【Numbering】BKME108007 【CAS】CAS
【Item No.】BKME10800712 【specification】
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Name: T-DLHN
Composition: cRGD peptide, camptothecin, cRGD-PEG-ace-HCPT-ace-acrylate polymer
Size: 100-200nm
Application: Antitumor activity
Storage conditions: -4℃
Other instructions: Half-year shelf life under sealed state [Main advantage] reversible "double lock" hydroxycamptothecin (HCPT) prodrug nanoparticles decorated with cyclic RGD peptide (cRGD) for safe and efficient chemotherapy of orthotopic lung cancer in mice; T-DLHN showed prolonged circulation time of about 5.0 hours, excellent lung tumor homing ability and tumor drug uptake of about 7.15%ID / g, thus significantly improving anti-tumor activity and reducing adverse effects

Title:Reversibly “double locked” hydroxycamptothecin prodrug nanoparticles for targeted chemotherapy of lung cancer

Article link:https://doi.org/10.1016/j.actbio.2023.05.030

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