DSF@Zn-DMSNs
| 【Numbering】BKMC105005 | 【CAS】CAS | ||
| 【Item No.】BKMC105005-2 | 【specification】 | ||
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Name: DSF @ Zn-DMSNs
Composition: zinc ion (Zn 2 +), loaded disulam (DSF), mesoporous silica nanoparticles
Particle size: 200nm
Application: Induction of cellular autophagy
Storage conditions: -4℃
Other instructions: Half-year shelf life in sealed state [Main advantage] This chelate not only significantly stimulates apoptosis and produces damage-related molecular patterns (DAMP), but also activates autophagy, thus mediating the amplified release of DAMP to enhance ICD. The in vivo results demonstrated that DSF @ Zn-DMSNs exhibited potent therapeutic effects through in situ ion chelation and the ability to activate autophagy, thereby enhancing immunotherapy by promoting the infiltration of T cells.
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Composition: zinc ion (Zn 2 +), loaded disulam (DSF), mesoporous silica nanoparticles
Particle size: 200nm
Application: Induction of cellular autophagy
Storage conditions: -4℃
Other instructions: Half-year shelf life in sealed state [Main advantage] This chelate not only significantly stimulates apoptosis and produces damage-related molecular patterns (DAMP), but also activates autophagy, thus mediating the amplified release of DAMP to enhance ICD. The in vivo results demonstrated that DSF @ Zn-DMSNs exhibited potent therapeutic effects through in situ ion chelation and the ability to activate autophagy, thereby enhancing immunotherapy by promoting the infiltration of T cells.
Title:Activation of autophagy by in situ Zn2+ chelation reaction for enhanced tumor chemoimmunotherapy
Article link:https://doi.org/10.1016/j.bioactmat.2023.06.022
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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