Multi-enzyme activity: catalase-like, superoxide dismutase-like, glutathione peroxidase-like, with antioxidant function; its catalase-like activity can decompose H2O2 in the tumor microenvironment. Ultrasonic oxygen , So as to solve the hypoxia problem of photodynamic therapy, sonodynamic therapy, and radiotherapy; its glutathione peroxidase activity can consume the antioxidant glutathione GSH in the tumor microenvironment, thereby promoting the above-mentioned pro-oxidation Treatment: After reacting with H2O2 and GSH, manganese oxide nanoenzyme degrades to Mn2+, which can promote Fenton reaction, catalyze H2O2 to generate hydroxyl free radicals, and further promote oxidation and treatment of tumors. At the same time, the produced Mn2+ has the function of magnetic resonance imaging; manganese oxide Generally, it has strong near-infrared light absorption capacity and can be used for photothermal therapy and photoacoustic imaging; Mn3O4 has certain magnetic properties and can be used for magnetic resonance imaging; decomposition of H2O2 produces oxygen bubbles, which can be used for ultrasound imaging; it can also be combined with chemotherapeutic drugs, Gene drugs and other realizing combination therapy.
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